Integrated Signal Transductions: Concepts and Approaches

Course content

The lecture is intended to provide an integrated perspective how various signal transduction circuits sense, amplify, and integrate extracellular signals to generate responses reflected as changes in enzyme activities, gene expressions and protein properties that affect cellular proliferation, growth, motility and death. The course introduce important classes of molecules in primary axial systems, specifically hypothelamo-hypophyseal-gonadal axis, that participate, and cross-talk, in signal-transduction pathways. The course also review how alterations in signaling circuits lead to pathologies and approaches to counter them. The course is critical in providing an outlook for interdisiplinary subjects that include biotechnology and biomedical engineering.